Insulinomics

Written by Mark Coles - Follow on Google+ | Facebook | Twitter

By Charles Poliquin

As athletes, we always seek to improve our performance. Of course, performance means nothing if we don’t fill our bodies with the best food, vitamins and supplements.

Poor management of carbohydrates, glucose, and insulin contribute to metabolic syndrome, insulin resistance, Type II Diabetes, and cardiovascular disease. Athletes can also expect to see a decrease in performance, muscle building, and fat burning.

We are pleased to offer a new formula from the PPC for improving insulin sensitivity and glucose uptake – Insulinomics UK.

You should consider supplementation if you fit the following profile:

  • Those with metabolic syndrome, insulin resistance, and blood sugar management problems
  • Anyone on a low-carb diet who wants to maximize their glucose uptake
  • Athletes that need to maximize their glycogen replenishment for performance and recovery
  • Carbohydrate addicts
  • Anyone that needs a nap after a high-carb meal
  • Considering Carbohydrate Consumption
  • What’s the most important thing to consider when it comes to carbohydrate consumption? We all know that carbohydrates are, for the most part, converted into glucose and then used as energy, right? But where are they used as energy? Inside the cell. Therefore, the most important thing to consider is getting the glucose inside the cell.

Here is how it’s supposed to work. When glucose rises in the bloodstream, the pancreas secretes insulin. Insulin binds to receptors in the cell membranes which in turn send signals inside the cell to tell transport vesicles to bring the glucose into the cell. On the other hand, glucose that stays outside the cell can eventually become glycated (forms a crusty protein layer) and is then converted to fat for storage. Glucose sitting outside the cell is like a guy that goes to the gym but just stands around outside, bothering the athletes going in while turning into a fat guy himself. So we want to make sure that guy gets in the gym and goes to work.

So where does this process go wrong? Much of the problem lies with the signaling that takes place at the cell membranes and within the cell. This signaling is accomplished by a complicated network of enzymes known as kinases.1 These kinases will basically either send messages of health or alarm. Signals of health allow the insulin receptors to function optimally. Unfortunately, poor diet and lifestyle choices switch these kinases into alarm mode. When messages of alarm are sent, inflammation increases and insulin receptors can be shut down. When the receptors shut down, blood sugar (glucose) stays elevated and insulin stays elevated.

Insulin, of course, is a storage hormone. It’s fine to elevate insulin if we can get it to signal into the cell to take up glucose, but if we can’t, then the glucose will be converted to fat and be stored in adipose tissue. According to the latest research, it gets even worse. Due to the altered kinase signaling, the fat can also become stored in the liver, the pancreas, and muscle tissue.2 The kinases responsible have names like PI3K, GSK, IKK, MSK, and SYK. Modulating these kinases to quiet down the alarm signals can improve physiology, accelerate glucose uptake, and decrease fat storage. The subsequent lowering of insulin will also allow fat to be mobilized for burning.

Modulating Kinases

Which leads us to the million-dollar question: How do we modulate these kinases?

There are various nutrients that can affect these kinases, but the most powerful tested to date are found in a proprietary new herbal formula now available in the PPC, called Insulinomics.

This formula contains very specific extracts of humulus lupulus and acacia nilotica. Extensive research at one of the few proteomic research centers in the country discovered (in animal, in-vitro, ex-vivo, and human studies) that it is from specific strains and extracts of these nutrients that kinase modulation can be achieved. This novel new formula can very selectively bring these kinases back into balance. Insulin sensitivity improves, glucose uptake improves, and fat storage decreases.

This not only has dramatic implications for people on the path to Type II Diabetes and cardiovascular disease, but athletes and sports nutritionists surely recognize that this could have huge implications for performance and recovery.

References:

1 Kruszynska, Yolanda T., et al “Fatty Acid-Induced Insulin Resistance: Decreased Muscle PI3K Activation but Unchanged Akt Phosphorylation” The Journal of Clinical Endocrinology & Metabolism Vol. 87, No 1 226-234, 2002.

2 McGarry, J. Denis, “Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes” Diabetes Vol. 51, January 2002.

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